If the roast is untied, tie at 3" intervals with cotton twine.
Rinse, pat dry with paper towel, let sit out for 45 minutes.
Preheat oven to 375F
Whisk seasoning rub together, and rub it all over the roast.
Place roast in pan, on a rack (or on top of cut veggies), cover, and cook for 20 minutes per pound. (uncovered)
When the roast is cooked to required doneness (see below), remove from oven, loosely cover with foil, and let rest.